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Diagnosis of Whipple's disease.

Chagas disease is caused by a protozoan parasite called Trypanosoma cruzi. Infection of humans occurs when an insect that carries the disease (mainly triatomine bugs or kissing bugs, members of this species and Reduviidae, sometimes called reduviidae bugs) leaves feces on human skin that contain parasites. Parasites enter the body of mammals (humans) through a bug bite, damage to the skin or conjunctiva. Sometimes parasites enter through the cells of the oral mucosa and respiratory tract, or by entering the respiratory tract. Bedbugs often contaminate the area around the eyes and lips with feces. When the parasites injure the skin, the area often becomes swollen and red (shagoma).


The third stage is characterized by specific brain damage, which is manifested by progressive dementia (dementia), and polyneuropathy. The heart also feels pathological influences - pericarditis (inflammation of naprosyn pills) and / or endocarditis (inflammation of the inner wall of the heart) develops.

The only method for reliable diagnosis of Whipple's disease is the morphological analysis of biopsy material taken from the mucous membrane in the upper small intestine. Other studies cannot provide doctors with accurate confirmation that the patient has the ailment in question.

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They only allow us to assess how far the disease has gone, which organs are affected, what digestive disorders are. These auxiliary diagnostic methods include: Complete blood count - to evaluate red blood counts and detect anemia. Biochemistry of naproxen - to determine the content of protein fractions. Blood tests for electrolytes, iron, calcium, vitamins. Endoscopic examination of the intestine is a method that allows you to visualize the mucous membrane of the digestive tube. Analysis of feces is coprological (steatorrhea is detected) and by PCR to identify the causative agent of the disease. MRI and CT - to check the condition of internal organs, pleural and pericardial cavities and lymph nodes. Ultrasound of the heart is indicative for endocarditis, pericarditis and pathologies of the valvular apparatus. Consultations of narrow specialists - depending on the symptoms found in the patient.

There are various antibiotic regimens, butThe two most commonly used are:

The main method of treating the disease in question is antibiotic therapy. Until it began to be used, patients died from exhaustion and disruption of the functioning of internal organs. An antibiotic of the tetracycline series is prescribed for 4-6 months daily, and then with a break of naprosyn for another 9-18 months. Ceftriaxone or meropenem in high doses is administered to patients intravenously for 2 weeks, after which they switch to taking biseptol or co-trimoxazole for another 12-18 months.

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Indicators that allow stopping treatment are remission, a negative PCR result, and the absence of the pathogen in biopsy specimens. In the cerebral form of Whipple's disease, antibiotic therapy is adjusted taking into account the ability of naprosyn drugs to penetrate the cellular barrier between blood and brain tissue. In severe cases, with a generalized process, antibiotics are prescribed in parallel with glucocorticosteroids.

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Another important component of the treatment of patients with Whipple's disease is symptomatic therapy. First of naproxen, the disorders associated with malabsorption and diarrheal syndrome are corrected. Such patients are prescribed: Special diet, which provides the body with essential amino acids, but does not load the digestive tract with fats. The diet is developed individually for each patient - taking into account the lack of weight and test results. Parenteral administration of amino acids and protein preparations. Balanced enzyme products - to improve the processes of digestion of food.

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Naproxen is used to relieve pain from various conditions such as headache, muscle aches, tendonitis, dental pain, and menstrual cramps.

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Medicines in this group are chosen based on the results of naprosyn and biochemical tests. Antispasmodics and antidiarrheal drugs. They alleviate discomfort, soreness and reduce the number of trips to the toilet. Enterosorbents for better removal of toxic products from the intestines. Equally important is the correction of vitamin and iron deficiency. Patients are prescribed antianemic drugs, as well as drugs containing vitamins B12, B6, B1, C and folic acid.

The prognosis for Whipple's disease depends on the stage of development of the disease and what kind of medical care the person receives. If there are no serious violations yet, against the background of adequate treatment, the patient recovers quite quickly. In the future, he needs to periodically undergo examinations and courses of maintenance therapy. If the disease is diagnosed late, the body has become very exhausted and the infectious-inflammatory process has spread from the intestine to other organs, naproxen will not be very favorable. Even worse is the situation with situations in which the patient does not receive any treatment at all. Such inactivity is a direct path to death.

Attention! The information is for informational purposes only and is not intended to diagnose or prescribe treatment. Always consult with a specialized doctor! General information What is Whipple's disease? Causes and risk factors What causes Whipple's disease? Risk factors Symptoms and complications Which organs are affected by Whipple's disease? Main symptoms and signs Possible complications Diagnosis Differential diagnosis Treatment Prognosis.

Whipple's disease is an infectious systemic disease, fortunately rare, caused by the bacterium Tropheryma whippelii. The distinguishing feature of this condition is the accumulation of lipid and glycoprotein material in the lining of the small intestine, in the lymphatic tissues of the mesentery, and in the lymph nodes, which is why Whipple's disease is also called intestinal lipodystrophy. The exact circumstances favoring infection with the bacterium are not yet known, but an immunological, acquired, or genetic predisposition has been identified.

The clinical picture of Whipple's disease is variable. The manifestation of this disease most affects the mucous membrane of the small intestine, but anaprox pills such as the heart, lungs, eyes and brain are also involved in the process. Patients typically suffer from abdominal pain, fever, weight loss, diarrhea, intestinal malabsorption (malabsorption in the intestines), skin hyperpigmentation, and polyarthralgia (pain felt in many joints simultaneously or sequentially).